- Colloidal dispersions of liposomes, polymersomes, emulsions
- Studies of particle clustering in the dispersion
- Electron-beam sensitive samples
- Low-temperature crystal phase studies
Cryo-TEM involves performing Transmission Electron Microscopy TEM analysis while keeping the sample at cryogenic temperatures, i.e. -170°C (or 103 K).
Transmission Electron Microscopy (TEM) is a technique that images a sample using an electron beam. High energy electrons (80keV-200keV) are transmitted through electron transparent samples (~100nm thick) and imaged on a plane.
The main reasons for the use of low temperature are
The production of thin (~100 nm) slices of frozen aqueous dispersions (‘vitrified ice layers’) is achieved using a Vitrobot ™ sample preparation tool, a dedicated cryo-sample-transfer unit and a cryo-TEM sample holder.
To enable certain features and improve your experience with us, this site stores cookies on your computer. Please click Continue to provide your authorization and permanently remove this message.